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劉燦榮教授

Tsan-Zon Liu (劉 燦 榮), Ph.D., F ACB, F-SFRBM

Education

B. S., National Taiwan University (1957-1961)
M. S. / Ph. D., University of California at Berkeley (1966-1971)

Professional experience

Postdoctoral Fellow, University of California, San Francisco (1971-1973)
NIH Postdoctoral Training for Clinical Pathology, University of California, San Francisco
(1973-1975)
Assistant Clinical Chemist, R & D Division, Clinical Laboratories, San Francisco General
Hospital and Department of Clinical Pathology, University of California, San Francisco
(1975-1978)
Assistant Professor, Center for Advanced Medical Technology, San Francisco State University
(1978-1981)
Associate Professor, Center for Advanced Medical Technology, San Francisco State University
(1981-1985)
Professor, Center for Advanced medical Technology, San Francisco State University
(1985-1989)
Professor/Chair, School of Medical Technology, Chang-Gung University (1989-1997)
Professor/Director, Department of Medical Research, Yuan’s General Hospital, Kaohsiung
(1997-2000)
Professor, Department of Medical Technology, Fooyin Institute of Technology (2000- 2001)
Professor, School of Medical Technology and Graduate Institute of Medical Biotechnology,
Chang Gung University, Taoyuan (2002-2009)
Consultant/Professor, Translational Research Lab. of Cancer Center, Taipei Medical University
Hospital, Taipei, Taiwan (2009 to present)
Editorial experience
Editor-in-Chief, “ Journal of Biomedical & Laboratory Sciences ” 1997-2005
Editorial Board Member, “ American Journal of Biomedical Sciences ” 2009-2011
Editorial Board Member, “ TUNGS’ Medical Journal ” 2007-2009
Editorial Board Member, “ Medical Journal of South Taiwan ” 2006-present

Honors

1960- President’s Award for outstanding undergraduate student (Book Scroll Award)
1973-74- NIH postdoctoral trainee in Clinical Pathology
1980- Appointed Research Associate at Cancer Research Institute, University of California at San Francisco
1980- Elected a member of National Academy of Clinical Biochemistry
1980-81- Recommended for Accelerated Tenure and Promotion by Clinical Science HRTP Committee and approved by the University Promotion Committee
1982- Clinical Chemist Recognition Award, American Association for Clinical Chemistry
1984- Invited to serve as consultant for Taipei Institute of Pathology
1984- Elected a member of the Association of Clinical Scientists
1986- Meritorous Performance and Professional Promise Award, San Francisco State University
1993- Best Poster Award (one of the fifteen among > 700 posters) XV International Congress of Clinical Chemistry, Melbourne, Australia. Nov. 14-19
1999- Beckman- Coulter Award- International presentation
2000- Outstanding Contributions to Clinical Chemistry Award, Northern California Chapter, American Association for Clinical Chemistry
2004- Sole invited speaker from Taiwan to attend International Symposium on Health-
Beneficial Effects of Prunus Mume, Seoul, Korea
2005- Distinguish Services Award, Taiwan Society of Laboratory Medicine
1997-2005- Editor-in-Chief, Jounal of Biomedical and Laboratory Science
2003-2005- President, Society for Free Radical Research (Taiwan)
2006- Listee of Leading Scientists of the world , International Biographical Center, Cambridge England
2013-Special Achievement Award, 2013 Biennial SFFR-Asia Meeting, Chang Gung University, Taiwan
2013-Inducted to the Fellow status of the Society of Free Radical Biology and Medicine (F-SFRBM) (First inductee from Asia)
Membership in Professional Societies Society for Free Radical Biology and Medicine (SFRBM) Association of Clinical Scientists National Academy of Clinical Biochemistry American Association for Clinical Chemistry Formosan Medical Association Specialty Clinical and Nutritional Biochemistry, Free Radical Biology & Medicine, Tumor Cell Biology, Clinical and Environmental Toxicology

Research Interests

1. Role of intracellular oxidative stress status (IOSS) in the modulation of metastatic propensity of Human hepatoma cell lines with varying degrees of differentiation.
2. Role of c-Myc expression and its translocation to the nucleus in the modulation of IOSS in HCC cells.
3. Direct visualization of endogenous ROS, GSH distribution, lipid peroxidation and mitochondrial alcium homeostasis in the modulation of oxidant-induces apoptotic cell death in HCC cells using confocal microscopy and flowcytometry.
4. Proteomic characterization of oxidatively modified proteins relevant to folate deficiency-induced apoptosis in Hep G2 cells.
5. Proteomic discovery of protein biomarkers relevant to differentiation status of hepatoma cells.
6. Study on the role of oxidative-nitrosative stress, glutathione redox imbalance, lipid peroxidation and mitochondrial calcium overload in the PDT of BPD-MA-induced apoptosis.
7. Hair multi-element analysis by ICP/MS and its clinical applications.
8. Probe-based ultraweak chemiluminescence method for analyzing oxygen-derived free radicals.
9. Biomarkers discovery for chemo- and radioresistance acquisition
10. Folate status and cancer progression/drug &RT resistance acquisition
11. Biomarkers discovery in the sera of HCC patients
12. Hydrogen Medicine